Double versus Single IUI

Intrauterine insemination (IUI) is usually performed once in a monthly cycle, but are there any advantages to double versus single IUI?

UNDERSTANDING IUI

IUI is an artificial insemination procedure where washed and concentrated sperm is inserted directly into the uterus using a slim catheter. The hope is that by placing the sperm into the uterus, it will increase the chances of the sperm making its way into the fallopian tube and fertilization will occur.

REASONS FOR PERFORMING IUI

A woman may undergo IUI if she is unable to achieve pregnancy, typically due to the following conditions:

• Unexplained infertility
• Mild male factor infertility
• When using donor sperm
• Single tube damage or blockage

IUI may be done in combination with ovarian stimulation and should be carefully timed, usually within 12 to 24 hours after an LH surge is detected or 12 to 36 hours after HCG is administered.

DOUBLE VS SINGLE IUI

IUI is typically performed only once per cycle (single IUI) on the day of ovulation.  In some cases, however, patients receive two inseminations on consecutive days, usually the day before and the day of ovulation. Research is mixed with the majority of studies revealing little to no increased success when double IUI versus single IUI is performed.  However some studies show that double IUI may improve the chance of conception in certain cases of male factor infertility, specifically when the initial sperm count is low.

Since research remains limited on the value of double IUI versus single, fertility specialists typically take into account each couple’s unique circumstance before deciding which method is best. However, evidence does show the most important factor of both double and single IUI is timing.